Bromine → 5-Bromo-2-hydroxy-4-methyl-3-nitropyridine

HRID 1387272

反応式

HRID 1387272 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[C:3]=1[N+:9]([O-:11])=[O:10].C([O-])(=O)C.[Na+].[Br:17]Br>C(O)(=O)C.C(OCC)(=O)C>[Br:17][C:7]1[C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[C:4](=[O:8])[NH:5][CH:6]=1

参加物

6

反応物 3

HCID 24408BromineHCID 3453702-Hydroxy-4-methyl-3-nitropyridineHCID 517045Sodium Acetate

生成物 1

HCID 217065175-Bromo-2-hydroxy-4-methyl-3-nitropyridine収率 90%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a stirred solution of 4-methyl-3-nitro-2-pyridone (0.45 g, 2.9 mmol) in glacial acetic acid (3 mL) was added sodium acetate (0.24 g) followed by bromine (0.15 mL) dropwise. After 5.5 hours, the mixture was diluted with ethyl acetate, washed with water, dried, filtered and concentrated to give 5-bromo-4-methyl-3-nitro-2-pyridone (0.62 g, 2.6 mmol, 90%).

後処理

  1. washwashed with water
  2. customdried
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-ff99ebcc0a0c492eb6637ad3ceb0939a
出典データセット
uspto-grants-2001_07
特許番号
US06268365B1

関連ノート

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