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Fluoride Ion → 5-Ethynyl-4-methyl-3-nitro-2-pyridone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Fluoride Ion | HCID 28179 | — |
| 反応物 | 5-Trimethylsilylethynyl-4-methyl-3-nitro-2-pyridone | HCID 21706491 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5-Ethynyl-4-methyl-3-nitro-2-pyridone | HCID 21706483 | 37.4% |
反応手順
To a stirred solution of 5-trimethylsilylethynyl-4-methyl-3-nitro-2-pyridone (1.0 g, 2.7 mmol) in THF (10 mL) was added tetrabutylammoniun fluoride (1M in THF, 2 mL). After 30 minutes the mixture was diluted with ethyl acetate, washed with water, dried, filtered and evaporated. Chromatography of the residue over silica gel (40% ethyl acetate/hexane) gave 5-ethynyl-4-methyl-3-nitro-2-pyridone (0.18 g, 22%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06268365B1 |
| 出典データセット | uspto-grants-2001_07 |
| ORD ID | ord-03f72c7b0e8c4a5f976b80856cdbb0bc |
| 出典メモ | uspto-grants-2001_07 |