2-Pyridinemethanol,a-(4-nitrophenyl)- → (4-Aminophenyl) (2-pyridyl)methanol

HRID 1387795ノート

反応式

HRID 1387795 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[CH:6][CH:5]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[CH:6][CH:5]=1

参加物

3

反応物 1

HCID 103537882-Pyridinemethanol,a-(4-nitrophenyl)-

生成物 1

HCID 10420323(4-Aminophenyl) (2-pyridyl)methanol収率 95%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In ethanol (50 ml) was dissolved (4-nitrophenyl)-(2-pyridyl)methanol (2.30 g), and to the mixture was added dried 10% palladium on carbon (0.12 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 19 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was recrystallized from ethyl acetate-hexane to give (4-aminophenyl) (2-pyridyl)methanol (1.90 g) as pale yellow crystals.

後処理

  1. additionto the mixture was added
  2. dry with materialdried 10% palladium on carbon (0.12 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated
  5. customThe residue was recrystallized from ethyl acetate-hexane

出典と根拠

ORDレコード
ord-3a5222d4713948329919980cefa2554d
出典データセット
uspto-grants-2001_07
特許番号
US06268354B1

反応ノート

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