1-Ethylpiperazine → HCID 3071010、化合物
反応式
Cl[C:2]1[N:6]([CH2:7][CH2:8][O:9][CH2:10][CH3:11])[C:5]2[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=2[N:3]=1.[CH2:16]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)[CH3:17].C(O)(=O)/C=C/C(O)=O>>[CH2:10]([O:9][CH2:8][CH2:7][N:6]1[C:5]2[CH:12]=[CH:13][CH:14]=[CH:15][C:4]=2[N:3]=[C:2]1[N:21]1[CH2:22][CH2:23][N:18]([CH2:16][CH3:17])[CH2:19][CH2:20]1)[CH3:11]参加物
4
実験手順
In the same manner as described in Example 1 using 2-chloro-1-[2-(ethoxy)ethyl]benzimidazole (5.00 g), N-ethylpiperazine (5.10 g) and fumaric acid (2.91 g), there are obtained curde crystals, which are recrystallized from ethyl acetate-ethanol to give 1-[2-(ethoxy)ethyl]-2-(4-ethyl-1-piperazinyl)benzimidazole.3/2 fumarate (5.62 g) as colorless needles, m.p. 134°-135.5° C.
後処理
- customare obtained curde crystals, which
- customare recrystallized from ethyl acetate-ethanol