Dichloromethane → 2-[(4-methylbenzoyl)amino]benzamide

HRID 1388235ノート

反応式

HRID 1388235 の反応式
[C:1]([NH2:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].C(Cl)Cl.C(N(CC)CC)C.[C:21]1([CH3:30])[CH:26]=[CH:25][C:24]([C:27](Cl)=[O:28])=[CH:23][CH:22]=1>O>[C:1]([C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:27]([C:24]1[CH:25]=[CH:26][C:21]([CH3:30])=[CH:22][CH:23]=1)=[O:28])(=[O:9])[NH2:10]

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 6942AnthranilamideHCID 8471TriethylamineHCID 134054-Methylbenzoyl Chloride

生成物 1

HCID 8196472-[(4-methylbenzoyl)amino]benzamide収率 88.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a well stirred mixture of anthranilamide (34.05 g; 0.25 mol), methylene chloride (650 ml) and triethylamine (~30 ml) is added p-toluoyl chloride (33 ml; 0.25 mol) dropwise over 25 minutes (a slight exotherm is noted). On completion of the addition, the reaction mixture is stirred for one hour, diluted with water (1000 ml). The mixture is stirred vigorously, filtered, the product washed with water and dried to afford 56.08 g solid, mp 206°-208° C.

後処理

  1. additionOn completion of the addition
  2. stirringthe reaction mixture is stirred for one hour
  3. stirringThe mixture is stirred vigorously
  4. filtrationfiltered
  5. washthe product washed with water
  6. customdried

出典と根拠

ORDレコード
ord-b9a99c6619c74900803ce805d66cd394
出典データセット
uspto-grants-1984_02
特許番号
US04431440

反応ノート

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