Hydrochloric Acid → 4-(Benzyloxy)-2-(hydroxyimino)-2,3-dihydro-1H-inden-1-one

HRID 1388295ノート

反応式

HRID 1388295 の反応式
[C:1]1([CH2:7][O:8][C:9]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:10]=2[CH2:11][CH2:12][C:13]3=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:19](OCCC(C)C)=[O:20].Cl>CCOCC>[OH:20][N:19]=[C:12]1[CH2:11][C:10]2[C:14](=[CH:15][CH:16]=[CH:17][C:9]=2[O:8][CH2:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:13]1=[O:18]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 136161924-(benzyloxy)-2,3-dihydro-1H-inden-1-one

生成物 1

HCID 714128754-(Benzyloxy)-2-(hydroxyimino)-2,3-dihydro-1H-inden-1-one収率 86%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To an ice-cooled solution of 1.91 g (0.008 m) of 4-(phenylmethoxy)-1-indanone in 75 ml of anhydrous ether is added dropwise with stirring 1.2 ml (0.088 m) of isoamyl nitrite while hydrogen chloride is simultaneously bubbled in. After stirring at room temperature for twenty minutes, the reaction mixture is partially concentrated and the solid which separates is filtered to yield 1.83 g (86%) of material sufficiently pure to be used in the next step.

後処理

  1. additionis added dropwise
  2. customis simultaneously bubbled in
  3. concentrationthe reaction mixture is partially concentrated
  4. filtrationthe solid which separates is filtered

出典と根拠

ORDレコード
ord-430e74d3c7b841a39e0c9156e5302765
出典データセット
uspto-grants-1984_02
特許番号
US04431647

反応ノート

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