4[3-(1H-imidazol-1-yl)propyl]-1-piperidinecarboxaldehyde → 4-[3-(1H-imidazol-1-yl)propyl]piperidine
反応式
[N:1]1([CH2:6][CH2:7][CH2:8][CH:9]2[CH2:14][CH2:13][N:12](C=O)[CH2:11][CH2:10]2)[CH:5]=[CH:4][N:3]=[CH:2]1>O1CCOCC1>[N:1]1([CH2:6][CH2:7][CH2:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:5]=[CH:4][N:3]=[CH:2]1参加物
3
実験手順
A mixture of 4[3-(1H-imidazol-1-yl)propyl]-1-piperidinecarboxaldehyde (2.12 g, 0.0095 M) in dioxane (80 ml) and 2 NHCl (11 ml) was refluxed for 51/2 hrs. After the reaction, the solvent was removed, water was added and the solution was basified with 2 N NaOH to pH 10 and extracted with CH2Cl2 (3×50 ml). The extracts were concentrated to give an oil (1.55 g, 80%). The dihydrochloride salt of the 4[3-(1H-imidazol-1-yl)propyl]-piperidine which was crystallized from acetone has m.p. 184°-186° C.
後処理
- temperaturewas refluxed for 51/2 hrs
- customAfter the reaction
- customthe solvent was removed
- additionwater was added
- extractionextracted with CH2Cl2 (3×50 ml)
- concentrationThe extracts were concentrated
出典と根拠
- ORDレコード
- ord-61d86af2ec8d4e009a511d5004ab17a5
- 出典データセット
- uspto-grants-1984_02
- 特許番号
- US04431653
反応ノート
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