Sodium ethoxide → 4-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine

HRID 1388399ノート

反応式

HRID 1388399 の反応式
[C:1]([CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)#N.C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH2:22]([NH:24][CH2:25][CH2:26][NH2:27])[CH3:23].[O-]CC.[Na+]>C(O)C>[CH2:22]([N:24]1[CH2:25][CH2:26][N:27]=[C:1]1[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)[CH3:23]

参加物

5

反応物 3

HCID 2723922Sodium ethoxideHCID 73304614-PyridinepropanenitrileHCID 20239798N-ethyl-1,2-diaminoethane mono-p-toluenesulfonate

生成物 1

HCID 137267364-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine収率 60%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

反応条件

温度
190 °C

実験手順

A mixture of 4-(2-cyanoethyl)pyridine (1.32 g, 0.01 M) and N-ethyl-1,2-diaminoethane mono-p-toluenesulfonate (5.5 g, 0.02 M) were heated at 190° C. for 4 hrs under nitrogen. The reaction mixture was dissolved in ethanol (30 ml) and sodium ethoxide (0.02 M) in ethanol (50 ml) was added. The mixture was filtered and the filtrate was stripped to dryness and distilled at 130° C./0.2 mmHg to yield 4-[2-(1-ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine (1.2 g, 60% yield).

後処理

  1. filtrationThe mixture was filtered
  2. distillationdistilled at 130° C./0.2 mmHg

出典と根拠

ORDレコード
ord-5f702cfa47bb4b20bd95424e45663a19
出典データセット
uspto-grants-1984_02
特許番号
US04431653

反応ノート

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