Hydrochloric Acid → 4-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidine

HRID 1388400ノート

反応式

HRID 1388400 の反応式
[CH2:1]([N:3]1[CH2:7][CH2:6][N:5]=[C:4]1[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1)[CH3:2].Cl>C(O)C.O.[Pt]=O>[CH2:1]([N:3]1[CH2:7][CH2:6][N:5]=[C:4]1[CH2:8][CH2:9][CH:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1)[CH3:2]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 137267364-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine

生成物 1

HCID 134731494-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidine収率 70.6%

試薬・触媒・溶媒 3

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

The solution of 4-[2-(1-ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine (1.1 g, 0.0054 M) in ethanol (15 ml) and water (15 ml) was added con.HCl (3 ml) and platinum oxide (0.2 g). The mixture was hydrogenated at 45 psig for 4 hrs. The catalyst was removed by filtration and the filtrate was stripped to dryness in vacuo. The residue was dissolved in methanol (25 ml) and sodium methoxide (0.011 M) was added and filtered. The filtrate was stripped to dryness and distilled at about 150° to about 175° C./0.2 mmHg to yield 4-[2-(1-ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidine as an oil (0.8 g, 70% yield).

後処理

  1. customThe catalyst was removed by filtration
  2. dissolutionThe residue was dissolved in methanol (25 ml)
  3. additionsodium methoxide (0.011 M) was added
  4. filtrationfiltered
  5. distillationdistilled at about 150° to about 175° C./0.2 mmHg

出典と根拠

ORDレコード
ord-fbcc5e7826a44f1ebf5a5211dc8a398f
出典データセット
uspto-grants-1984_02
特許番号
US04431653

反応ノート

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