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Diazomethane → Ethyl 4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diazomethane | HCID 9550 | — |
| 反応物 | N-Methyl-N-nitrosourea | HCID 12699 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Ethyl 3-ethoxycarbonyl-4-hydroxy-1-methylpyrrole-2-acetate | HCID 13345719 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Ethyl 4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate | HCID 20469092 | — |
反応手順
Ethyl 4-hydroxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate (20 mmole) is dissolved in 10 μl of diethyl ether containing diazomethane freshly prepared from N-methyl-N-nitrosourea and potassium hydroxide. After the reaction is allowed to stand at room temperature for about 0.5 hour, the ether is evaporated under reduced pressure at mild temperature and the residue, i.e., crude ethyl-4-methoxy-3-ethoxycarbonyl-1-methylpyrrole-2-acetate, is used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04434175 |
| 出典データセット | uspto-grants-1984_02 |
| ORD ID | ord-195bafe7bb434b3881f51fa3bf30cad8 |
| 出典メモ | uspto-grants-1984_02 |