HCID 54095551、化合物 → Ethyl 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylate

HRID 1389005ノート

反応式

HRID 1389005 の反応式
[CH2:1]([O:3][C:4](=[O:22])[C:5]([C:10](=[O:21])[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=1)=[CH:6][N:7](C)C)[CH3:2].C(OC(=O)C(C(=O)C1C=CC(Cl)=CC=1Cl)=CN(C)C)C>>[CH2:1]([O:3][C:4]([C:5]1[CH:6]=[N:7][O:21][C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=1)=[O:22])[CH3:2]

参加物

3

反応物 2

HCID 54095551HCID 54095551、化合物HCID 54156258Ethyl 3-dimethylamino-2-(4-trifluoromethyl-benzoyl)-acrylate

生成物 1

HCID 22221374Ethyl 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylate収率 47%

実験手順

The procedure of Example 12 was employed utilizing ethyl-2-(4'-trifluoromethylbenzoyl)-3-dimethylaminopropenoate in lieu of ethyl-2-(2',4'-dichlorobenzoyl)-3-dimethylaminopropenoate to yield ethyl-5-(4'-trifluoromethylphenyl)-4-isoxazolecarboxylate (2.03 g.; 47% yield) as yellow crystals having a melting point of 42°-44° C. and the following analysis:

出典と根拠

ORDレコード
ord-381ab027cddc4f19a00c01c9d831e519
出典データセット
uspto-grants-1981_01
特許番号
US04243406

反応ノート

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