N-Butylnicotinamide → HCID 20298115、化合物
反応式
[CH2:1]([NH:5][C:6](=[O:13])[C:7]1[CH:12]=[CH:11][CH:10]=[N:9][CH:8]=1)[CH2:2][CH2:3][CH3:4]>C(O)(=O)C.[Pt]=O>[CH2:1]([NH:5][C:6]([CH:7]1[CH2:12][CH2:11][CH2:10][NH:9][CH2:8]1)=[O:13])[CH2:2][CH2:3][CH3:4]参加物
4
実験手順
N-n-Butylnicotinamide (7.0 g) in acetic acid (100 ml) was hydrogenated over platinum oxide at 50° and 50 p.s.i. The catalyst was removed by filtration, the filtrate evaporated and the residue treated with toluene and evaporated in vacuo. The residue in chloroform (50 ml) was washed with sodium bicarbonate solution (3×50 ml) the organic layer separated, dried (Na2SO4) and the solvent evaporated in vacuo to give as an oil 3-(N-n-butylcarbamoyl)piperidine (3.8 g).
後処理
- customThe catalyst was removed by filtration
- customthe filtrate evaporated
- additionthe residue treated with toluene
- customevaporated in vacuo
- washThe residue in chloroform (50 ml) was washed with sodium bicarbonate solution (3×50 ml) the organic layer
- customseparated
- dry with materialdried (Na2SO4)
- customthe solvent evaporated in vacuo
出典と根拠
- ORDレコード
- ord-f3921004db8d40858362aff62f74763d
- 出典データセット
- uspto-grants-1981_01
- 特許番号
- US04243666
反応ノート
読み込み中…