Epichlorohydrin → HCID 20298522、化合物

反応式

[CH2:1]([CH:3]1[O:5][CH2:4]1)Cl.[CH3:6][C:7]1[CH:12]=[C:11]([S:13][CH3:14])[CH:10]=[CH:9][C:8]=1[OH:15].[CH2:16]([NH2:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]>>[CH3:6][C:7]1[CH:12]=[C:11]([S:13][CH3:14])[CH:10]=[CH:9][C:8]=1[O:15][CH2:1][CH:3]([OH:5])[CH2:4][NH:24][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

参加物

反応物 3

HCID 7835Epichlorohydrin

HCID 8143Octylamine

HCID 138054o-Cresol, 4-methylthio-

生成物 1

HCID 20298522HCID 20298522、化合物収率 19%

実験手順

The epichlorohydrin derivative of 2-methyl-4-(methylthio)phenol (3.14 g., 0.015 mole) is reacted with n-octylamine (1.93 g. 0.015 mole) according to the procedure of Example 1. Concentrating the reaction mixture and crystallization of residual material from ethylacetate-hexane affords a 19% yield of analytically pure 1-[2-methyl-4-(methylthio)phenoxy]-3-(octylamino)-2-propanol, m.p. 59°-60° (corr.).

後処理

concentrationConcentrating
customthe reaction mixture and crystallization of residual material from ethylacetate-hexane

出典と根拠

ORDレコード: ord-9af9e2f972ae4f0b81e4312a19525958
出典データセット: uspto-grants-1981_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04243681

反応ノート

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