Benzylamine → 4-(Benzylamino)butanenitrile

HRID 1389203ノート

反応式

HRID 1389203 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:10][CH2:11][CH2:12][C:13]#[N:14].C1CCCCC1.Br.C(N)C1C=CC=CC=1>C(OCC)C>[CH2:1]([NH:8][CH2:10][CH2:11][CH2:12][C:13]#[N:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 7504BenzylamineHCID 8078CyclohexaneHCID 214124-BromobutyronitrileHCID 129985681-Phenylmethanamine--hydrogen bromide (1/1)

生成物 1

HCID 30145704-(Benzylamino)butanenitrile収率 66%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

32.2 g of benzylamine, 14.8 g of 4-bromobutyronitrile and 30 ml of cyclohexane are stirred at room temperature for 12 hours. After the addition of diethyl ether the separated benzylamine hydrobromide is filtered off; the ether phase is washed with water, dried and concentrated by evaporation. The residue is distilled in vacuo to yield 11.5 g (66% of theory) of 4-benzylaminobutyronitrile (B.P. 114° to 120°/0.05 mm Hg).

後処理

  1. filtrationis filtered off
  2. washthe ether phase is washed with water
  3. customdried
  4. concentrationconcentrated by evaporation
  5. distillationThe residue is distilled in vacuo

出典と根拠

ORDレコード
ord-3d7c63796250464c962ef37264c77f02
出典データセット
uspto-grants-1981_01
特許番号
US04243678

反応ノート

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