Hydrochloric Acid → 4-(Phenoxymethyl)piperidine--hydrogen chloride (1/1)

HRID 1389236ノート

反応式

HRID 1389236 の反応式
[O:1]([CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:15]>[Pt]=O.CO>[ClH:15].[O:1]([CH2:8][CH:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 12472531HCID 12472531、化合物

生成物 1

HCID 441449484-(Phenoxymethyl)piperidine--hydrogen chloride (1/1)収率 53%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 887Methanol溶媒

実験手順

A mixture of 18.5 g (0.1 mole) of 4-phenoxymethylpyridine, 250 ml of methanol, 250 ml of 3 N methanolic hydrogen chloride solution and 2 g of platinum oxide is shaken at ambient temperature under a hydrogen pressure of 1 atmosphere absolute. After the take up of the calculated amount of hydrogen, the catalyst is filtered off, the filtrate is evaporated in a vacuum and the residue is recrystallized from ethanol. There are obtained 12.0 g of 4-phenoxymethylpiperidine hydrochloride (53% of theory); m.p. 218°-219° C. The free base is obtained by treating the hydrochloride with an aqueous solution of sodium hydroxide.

後処理

  1. filtrationAfter the take up of the calculated amount of hydrogen, the catalyst is filtered off
  2. customthe filtrate is evaporated in a vacuum
  3. customthe residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-f4fc3fe9d3f941be8b38728abf96677f
出典データセット
uspto-grants-1981_01
特許番号
US04243807

反応ノート

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