3-Amino-4-(propylamino)benzoic acid → 2-Methyl-1-propyl-1,3-benzodiazole-5-carboxylic acid

HRID 1389299ノート

反応式

HRID 1389299 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[NH:11][CH2:12][CH2:13][CH3:14])[C:5]([OH:7])=[O:6].Cl.[CH2:16](C(=N)OCC)[CH3:17]>C(O)(=O)C>[CH3:16][C:17]1[N:11]([CH2:12][CH2:13][CH3:14])[C:10]2[CH:9]=[CH:8][C:4]([C:5]([OH:7])=[O:6])=[CH:3][C:2]=2[N:1]=1

参加物

4

反応物 2

HCID 115864403-Amino-4-(propylamino)benzoic acidHCID 13000588Ethyl propanecarboximidate hydrochloride

生成物 1

HCID 202988562-Methyl-1-propyl-1,3-benzodiazole-5-carboxylic acid

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 4.5 parts of 3-amino-4-(propylamino)-benzoic acid, 2.6 parts of ethyl ethanecarboximidate hydrochloride and 50 parts of acetic acid is stirred first for 20 minutes at room temperature and further for 10 minutes at reflux. The reaction mixture is evaporated. The residue is crystallized from 2-propanol. The product is filtered off, washed with water and 2-propanol and dried, yielding 1.8 parts of 2-methyl-1-propyl-1H-benzimidazole-5-carboxylic acid; mp.<260° C.

後処理

  1. temperatureat reflux
  2. customThe reaction mixture is evaporated
  3. customThe residue is crystallized from 2-propanol
  4. filtrationThe product is filtered off
  5. washwashed with water and 2-propanol
  6. customdried

出典と根拠

ORDレコード
ord-bf8cd5efcb15429c92604b255356444d
出典データセット
uspto-grants-1981_01
特許番号
US04243806

反応ノート

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