2-Bromoisovaleric acid → N-(2-fluoro-4-chlorophenyl)valine
反応式
[F:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH2:4].Br[CH:11]([CH:15]([CH3:17])[CH3:16])[C:12]([OH:14])=[O:13]>>[F:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH:4][C@H:11]([C:12]([OH:14])=[O:13])[CH:15]([CH3:17])[CH3:16]参加物
3
実験手順
Following the procedure of Example 17, N-(2-fluoro-4-chlorophenyl)valine (0.79 g) is reacted with α-ethynyl-m-phenoxybenzyl bromide (0.39 g) to yield the α-ethynyl-m-phenoxybenzyl ester of N-(2-fluoro-4-chlorophenyl)valine, MS m/e 451 (M+). N-(2-fluoro-4-chlorophenyl)valine is prepared from 2-fluoro-4-chloroaniline and α-bromoisovaleric acid using the procedure of Example 17.
出典と根拠
- ORDレコード
- ord-9d1af699e82d41df954b1ed8d0a82ffd
- 出典データセット
- uspto-grants-1981_01
- 特許番号
- US04243819
反応ノート
読み込み中…