Methane → 5-Bromo-N-methanesulfonylpentanamide
反応式
[CH3:1][S:2]([NH2:5])(=[O:4])=[O:3].[Br:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12].C>C(Cl)Cl>[CH3:1][S:2]([NH:5][C:11](=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][Br:6])(=[O:4])=[O:3]参加物
5
実験手順
A mixture of 0.950 g (0.01 mole) of methanesulfonamide and 1.80 g. (0.01 mole) of 5-bromovaleric acid chloride was heated on a steam bath until gas evolution ceased (ca. 5 minutes). The brown reaction mixture was allowed to cool and was dissolved in methylene chloride. The methylene chloride solution was treated with Darco, was filtered, and was diluted with hexane with cooling to afford the white, crystalline N-methanesulfonyl-5-bromovaleramide weighing 2.22 g. (86.0% yield) which melted at 88°-89°.
後処理
- custom(ca. 5 minutes)
- temperatureto cool
- filtrationwas filtered
- additionwas diluted with hexane
- temperaturewith cooling
出典と根拠
- ORDレコード
- ord-ccda27c2fe5c41eea6cfe8975ef8b3a8
- 出典データセット
- uspto-grants-1981_01
- 特許番号
- US04244887
反応ノート
読み込み中…