Methane → 5-Bromo-N-methanesulfonylpentanamide

HRID 1389412

反応式

HRID 1389412 の反応式
[CH3:1][S:2]([NH2:5])(=[O:4])=[O:3].[Br:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12].C>C(Cl)Cl>[CH3:1][S:2]([NH:5][C:11](=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7][Br:6])(=[O:4])=[O:3]

参加物

5

反応物 3

HCID 297MethaneHCID 72879MethanesulfonamideHCID 5211735-Bromovaleryl chloride

生成物 1

HCID 202961415-Bromo-N-methanesulfonylpentanamide収率 86%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A mixture of 0.950 g (0.01 mole) of methanesulfonamide and 1.80 g. (0.01 mole) of 5-bromovaleric acid chloride was heated on a steam bath until gas evolution ceased (ca. 5 minutes). The brown reaction mixture was allowed to cool and was dissolved in methylene chloride. The methylene chloride solution was treated with Darco, was filtered, and was diluted with hexane with cooling to afford the white, crystalline N-methanesulfonyl-5-bromovaleramide weighing 2.22 g. (86.0% yield) which melted at 88°-89°.

後処理

  1. custom(ca. 5 minutes)
  2. temperatureto cool
  3. filtrationwas filtered
  4. additionwas diluted with hexane
  5. temperaturewith cooling

出典と根拠

ORDレコード
ord-ccda27c2fe5c41eea6cfe8975ef8b3a8
出典データセット
uspto-grants-1981_01
特許番号
US04244887

関連ノート

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