Imidazole → 1-(1,1'-Biphenyl)-4-yl-2-(1H-imidazol-1-yl)ethanone

HRID 1389779ノート

反応式

HRID 1389779 の反応式
[C:1]1([C:7]2[CH:16]=[CH:15][C:10]([C:11](=[O:14])[CH2:12]Br)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.O>CN(C)C=O>[N:17]1([CH2:12][C:11]([C:10]2[CH:15]=[CH:16][C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:8][CH:9]=2)=[O:14])[CH:21]=[CH:20][N:19]=[CH:18]1

参加物

5

反応物 3

HCID 795ImidazoleHCID 962WaterHCID 672821-(1,1'-Biphenyl)-4-yl-2-bromoethanone

生成物 1

HCID 517091-(1,1'-Biphenyl)-4-yl-2-(1H-imidazol-1-yl)ethanone収率 65.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

39 g (0.14 mol) of 4-phenylphenacyl bromide are introduced in portions into a solution of 48.2 g (0.7 mol) of imidazole in 140 ml of dimethylformamide, whilst cooling. The mixture is allowed to subsequently react for 15 hours and the solution is poured into water. The crystal mass which has separated out is recrystallised from ethanol. 24 g (65% of theory) of 4-biphenylyl imidazol-1-yl-methyl ketone of melting point 198° C. are obtained.

後処理

  1. temperaturewhilst cooling
  2. customto subsequently react for 15 hours
  3. customThe crystal mass which has separated out
  4. customis recrystallised from ethanol

出典と根拠

ORDレコード
ord-30f59f05e9d541cc8c788b4ef056d9b6
出典データセット
uspto-grants-1981_01
特許番号
US04246274

反応ノート

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