2,2,2-Trichloroethyl chloroformate → N-(beta,beta,beta-trichloroethoxycarbonyl)-3-pyrroline
反応式
C([N:8]1[CH2:12][CH:11]=[CH:10][CH2:9]1)C1C=CC=CC=1.Cl[C:14]([O:16][CH2:17][C:18]([Cl:21])([Cl:20])[Cl:19])=[O:15]>C1C=CC=CC=1>[Cl:19][C:18]([Cl:21])([Cl:20])[CH2:17][O:16][C:14]([N:8]1[CH2:12][CH:11]=[CH:10][CH2:9]1)=[O:15]参加物
4
実験手順
40.0 g (0.25 mol) of N-benzyl-3-pyrroline are dissolved in 400 ml of benzene. 53.0 g (0.25 mol) of 2,2,2-trichloroethyl chloroformate are introduced into this solution in the course of 30 minutes, at 0° and under a nitrogen atmosphere. The reaction mixture is stirred for a further 1 hour at 0°, then washed at room temperature twice with, in each case, 100 ml of a mixture of water and 2 N hydrochloric acid (3:1) and then twice with water, dried over sodium sulphate and evaporated under a water pump vacuum. The oily residue is distilled under a high vacuum and, after 24 g of benzyl chloride has been separated off, N-(β,β,β-trichloroethoxycarbonyl)-3-pyrroline with a boiling point of 84°-85° C./0.12 mm Hg is obtained.