Potassium Iodide → 4-[4-(6-Chloro-2-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone

HRID 1389876ノート

反応式

HRID 1389876 の反応式
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[C:15]([Cl:20])[CH:16]=3)[CH:11]=2)=[O:9])[CH2:4][CH2:3]1.Cl[CH2:22][CH2:23][CH2:24][C:25]([C:27]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=1)=[O:26].C(=O)(O)[O-].[K+].[I-].[K+]>C1(C)C=CC=CC=1>[Cl:20][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:8]([CH:5]1[CH2:6][CH2:7][N:2]([CH2:22][CH2:23][CH2:24][C:25]([C:27]3[CH:28]=[CH:29][C:30]([F:33])=[CH:31][CH:32]=3)=[O:26])[CH2:3][CH2:4]1)=[O:9])[CH:19]=[CH:18]2

参加物

6

反応物 4

HCID 4875Potassium IodideHCID 197503-(4-Fluorobenzoyl)propyl chlorideHCID 516893Potassium BicarbonateHCID 705701616-Chloro-2-naphthyl 4-piperidyl ketone hydrochloride

生成物 1

HCID 202956124-[4-(6-Chloro-2-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of 3.43 g (12.5 mmoles) of 6-chloro-2-naphthyl 4-piperidyl ketone hydrochloride, 2.63 g (13.1 mmoles) of 4-chloro-1-(4-fluorophenyl)-1-butanone, 2.6 g (26 mmoles) of potassium bicarbonate and a pinch of potassium iodide in 60 ml of toluene is heated at reflux for 80 hours. The mixture is partitioned between toluene and water and the organic phase washed with brine, dried over magnesium sulfate, and concentrated in vacuo to yield 4-[4-(6-chloro-2-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone.

後処理

  1. temperatureat reflux for 80 hours
  2. customThe mixture is partitioned between toluene and water
  3. washthe organic phase washed with brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-f86c3843cd534d10a41d1dcda6c13f9f
出典データセット
uspto-grants-1981_01
特許番号
US04246268

反応ノート

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