2,5-Hexanedione → HCID 20294652、化合物

反応式

Cl.Cl.[NH:3]([C:5]1[N:6]=[N:7][C:8]([N:11]2[CH2:16][CH2:15][S:14][CH2:13][CH2:12]2)=[CH:9][CH:10]=1)[NH2:4].[CH3:17][C:18](=O)[CH2:19][CH2:20][C:21](=O)[CH3:22].C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH3:22][C:21]1[N:4]([NH:3][C:5]2[N:6]=[N:7][C:8]([N:11]3[CH2:16][CH2:15][S:14][CH2:13][CH2:12]3)=[CH:9][CH:10]=2)[C:18]([CH3:17])=[CH:19][CH:20]=1

参加物

実験手順

3-Hydrazino-6-(4-thiomorpholinyl)-pyridazine di-hydrochloride and 2,5-hexanedione are reacted in acetic acid in the presence of sodium acetate according to the procedure of example 2. The product is recovered by evaporating the acetic acid and slurring the residue in aqueous sodium bicarbonate. The solid obtained after filtration is purified by chromatography through silicagel using a chloroform-methanol mixture 97.5:2.5 mixture as the eluent. Yield 50%. M.p. 203° C. (from ethyl acetate). Elemental analysis, I.R. and N.M.R. data are in agreement with the assigned structure.