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Isocyanic acid → 2,5-Dimethyl-3,6-di(propan-2-yl)pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isocyanic acid | HCID 6347 | — |
| 反応物 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 反応物 | Nitrosyl chloride | HCID 17601 | — |
| 反応物 | 4-Methyl-3-oximino-2-pentanone | HCID 6795112 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2,5-Dimethyl-3,6-di(propan-2-yl)pyrazine | HCID 13320992 | — |
反応手順
d. 2,5-Dimethyl-3,6-diisopropyl-pyrazine was prepared by first forming 4-methyl-3-oximino-2-pentanone by reacting 4-methyl-2-pentanone with nitrosyl chloride according to the method of BOUVEAULT, Bull. [3] 31, 1163 (1904). The autocondensation of two moles of the imino-ketone in the presence of zinc and acetic acid [according to the method described in Chimia, 11, 310 (1957)] yielded 2,5-Dimethyl-3,6-diisopropyl-pyrazine which had a b.p. of 91° C./8 mm. Hg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04138410 |
| 出典データセット | uspto-grants-1979_02 |
| ORD ID | ord-a9bdd9174ff34b39ad44f9617c6492e7 |
| 出典メモ | uspto-grants-1979_02 |