関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Aminosalicylic Acid | HCID 4649 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Acetamidosalicylic acid | HCID 65509 | 92% |
反応手順
30.6 grs (0.2 mol) p-aminosalicylic acid and 100 cc ethanol were introduced into a 250 ml flask, and the mixture was heated to 40° C. 20.4 grs (0.2 mol) acetic anhydride was then added at such a rate that the temperature did not exceed 50° C. When the addition was complete, the mixture was stirred at 50° C. for 3 hours. The product was filtered. Weight: 36 grs m.p. = 235° C. Yield = 92%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04138492 |
|---|
| 出典データセット | uspto-grants-1979_02 |
|---|
| ORD ID | ord-2ee3b3f9ce1b4fca9b70562dc0279e06 |
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| 出典メモ | uspto-grants-1979_02 |
|---|
