化工社化工社 化学情報印刷レポート · 研究参考用
2-Pyrrolidone → N-(m-Trifluoromethylphenyl)-3-methylthio-4-chloromethyl-2pyrrolidone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Pyrrolidone | HCID 12025 | — |
| 反応物 | Flurochloridone | HCID 91677 | — |
| 反応物 | Sodium methanethiolate | HCID 4378561 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-(m-Trifluoromethylphenyl)-3-methylthio-4-chloromethyl-2pyrrolidone | HCID 22748887 | 85% |
反応手順
In the same manner as descried above for Example 1, sodium methyl mercaptide prepared from 6.5 g of a 25% methanol solution of sodium methoxide in 50 ml of dimethylformamide was added to 9.4 g (0.034 mole) of N-(m-trifluoromethylphenyl)-3-chloro-4-chloromethyl-2-pyrrolidone (prepared according to the procedure described in U.S. Pat. No. 4,069,038). The product weighed 9.3 g, representing 85% yield based on the pyrrolidone, structure confirmed by NMR analysis, with refractive index nD30 =1.5028. This compound is shown in Table I as Compound No. 2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04138495 |
| 出典データセット | uspto-grants-1979_02 |
| ORD ID | ord-163e4b15a7334f219965573c1058670e |
| 出典メモ | uspto-grants-1979_02 |