Sodium Methoxide → HCID 178493753、化合物

HRID 1390310ノート

反応式

HRID 1390310 の反応式
COC([C:5]1[C:10]([O:11][CH3:12])=[CH:9][N:8]=[CH:7][N:6]=1)=O.ClC1C([C:20](OCC)=[O:21])=NC=NC=1.[CH3:25][O-:26].[Na+]>CO>[CH3:12][O:11][C:10]1[C:5]([O:26][CH3:25])=[N:6][C:7](=[C:20]=[O:21])[NH:8][CH:9]=1

参加物

5

反応物 3

HCID 10942334Sodium MethoxideHCID 21329182Ethyl 5-chloropyrimidine-4-carboxylateHCID 21329223Methyl 5-methoxy-4-pyrimidinecarboxylate

生成物 1

HCID 178493753HCID 178493753、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4-Methoxycarbonyl-5-methoxypyrimidine can be prepared by heating 5-chloro-4-ethoxycarbonylpyrimidine (23 g) with sodium methoxide (15 g) in methanol (230 cc) for 8 hours. The solvent is evaporated off and the residue is suspended in diethyl ether (1000 cc). The suspension is washed with water (50 cc). The organic phase is dried over sodium sulphate, filtered and concentrated to dryness to give 5-methoxy-4-methoxy-carbonylpyrimidine (6 g) melting at 75° C.

後処理

  1. customThe solvent is evaporated off
  2. washThe suspension is washed with water (50 cc)
  3. dry with materialThe organic phase is dried over sodium sulphate
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-1fc770e71a25494a86f55a7b764debea
出典データセット
uspto-grants-1979_02
特許番号
US04138487

反応ノート

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