3-t-Butyldimethylsiloxy-1-iodo-trans-1-octene → HCID 178506904、化合物

HRID 1390696ノート

反応式

HRID 1390696 の反応式
[O:1]([CH:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])/[CH:10]=[CH:11]/I)[Si:2]([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3].C([Li:22])CCC>CCCCCC>[O:1]([CH:9]([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])/[CH:10]=[CH:11]/[Li:22])[Si:2]([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3]

参加物

4

反応物 2

HCID 109485973-t-Butyldimethylsiloxy-1-iodo-trans-1-octeneHCID 178418339Butyllithium

生成物 1

HCID 178506904HCID 178506904、化合物

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒3 回

反応条件

温度
-78 °C

実験手順

On the other hand, 442 mg (1.2 mmol) of 3-t-butyldimethylsiloxy-1-iodo-trans-1-octene was added to 2 ml of anhydrous hexane, and 1 ml (1.2 mmol) of a 1.2 M hexane solution of n-butyllithium was added. The mixture was stirred at -78° C. for 30 minutes in an atmosphere of nitrogen to afford an anhydrous hexane solution of 3-t-butyldimethylsiloxy-1-lithio-trans-1-octene. The resulting solution was added dropwise to the anhydrous diethyl ether solution of copper pentylide prepared previously, and the mixture was stirred at -78° C. for 30 minutes in an atmosphere of nitrogen to afford a solution of an organic copper lithium compound of the following formula ##STR20##

後処理

  1. additionwas added

出典と根拠

ORDレコード
ord-94edbdbc81cd408b92ea7568790b37dd
出典データセット
uspto-grants-1979_02
特許番号
US04139717

反応ノート

読み込み中…