4-Methyl-4,6-androstadiene-3,17,19-trione → 4alpha,7alpha-Dimethyl-5-androstene-3,17,19-trione

HRID 1390748

反応式

HRID 1390748 の反応式
[CH3:1][C:2]1[C:19](=[O:20])[CH2:18][CH2:17][C@@:16]2([CH:21]=[O:22])[C:3]=1[CH:4]=[CH:5][C@@H:6]1[C@@H:15]2[CH2:14][CH2:13][C@@:11]2([CH3:12])[C@H:7]1[CH2:8][CH2:9][C:10]2=[O:23].O[C@@:25]1(C)CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@]1(C=O)C(=CC(=O)CC1)C=C3.[OH:47][C@@:48]1([C:69]#[C:70][CH3:71])[CH2:53][CH2:52][C@H:51]2[C@H:54]3[C@H:65]([CH2:66][CH2:67][C@:49]12[CH3:50])[C@:62]1([CH:63]=[O:64])[C:57](=[CH:58][C:59](=[O:68])[CH2:60][CH2:61]1)[CH:56]=[CH:55]3.[CH3:72][C@]12CC[C@H]3[C@@H](C=CC4[C@]3(C=O)CCC(=O)C=4)[C@@H]1CCC2=O>>[CH3:1][C@@H:2]1[C:19](=[O:20])[CH2:18][CH2:17][C@@:16]2([CH:21]=[O:22])[C:3]1=[CH:4][C@@H:5]([CH3:25])[C@@H:6]1[C@@H:15]2[CH2:14][CH2:13][C@@:11]2([CH3:12])[C@H:7]1[CH2:8][CH2:9][C:10]2=[O:23].[OH:47][C@@:48]1([C:69]#[C:70][CH3:71])[CH2:53][CH2:52][C@H:51]2[C@H:54]3[C@H:65]([CH2:66][CH2:67][C@:49]12[CH3:50])[C@:62]1([CH:63]=[O:64])[C:57]([CH2:58][C:59](=[O:68])[CH2:60][CH2:61]1)=[CH:56][C@H:55]3[CH3:72]

参加物

6

反応物 4

HCID 537200574-Methyl-4,6-androstadiene-3,17,19-trioneHCID 537511734,6-Androstadiene-3,17,19-trioneHCID 8673569317beta-Hydroxy-17alpha-methyl-4,6-androstadiene-3,19-dioneHCID 13171109617beta-Hydroxy-17alpha-propinyl-4,6-androstadiene-3,19-dione

生成物 2

HCID 867363124alpha,7alpha-Dimethyl-5-androstene-3,17,19-trioneHCID 13171142617beta-Hydroxy-7alpha-methyl-17alpha-propinyl-5-androstene-3,19-dione

実験手順

Substituting 4-methyl-4,6-androstadiene-3,17,19-trione, 17β-hydroxy-17α-methyl-4,6-androstadiene-3,19-dione and 17β-hydroxy-17α-propinyl-4,6-androstadiene-3,19-dione for the 4,6-androstadiene-3,17,19-trione above results in the formation of 4α,7α-dimethyl-5-androstene-3,17,19-trione, 17β-hydroxy-7α,17α-dimethyl-5-androstene-3,19-dione, and 17β-hydroxy-7α-methyl-17α-propinyl-5-androstene-3,19-dione, respectively.

出典と根拠

ORDレコード
ord-43821d57beb44f19a9e3187fe0041fc5
出典データセット
uspto-grants-1979_02
特許番号
US04139617

関連ノート

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