Water → HCID 86736330、化合物

HRID 1390788ノート

反応式

HRID 1390788 の反応式
[C:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:25]([CH2:26][CH2:27][C@:6]12[CH3:7])[C@:19]1([CH2:20][O:21][C:22](=[O:24])[CH3:23])[C:14]([CH2:15][C@@H:16]([OH:28])[CH2:17][CH2:18]1)=[CH:13][CH2:12]3)(=[O:3])[CH3:2].F[B-](F)(F)F.[CH2:34]([O+](CC)CC)[CH3:35].O>C(Cl)Cl>[C:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:25]([CH2:26][CH2:27][C@:6]12[CH3:7])[C@:19]1([CH2:20][O:21][C:22](=[O:24])[CH3:23])[C:14]([CH2:15][C@@H:16]([O:28][CH2:34][CH3:35])[CH2:17][CH2:18]1)=[CH:13][CH2:12]3)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 962WaterHCID 2723982Triethyloxonium tetrafluoroborateHCID 70604761HCID 70604761、化合物

生成物 1

HCID 86736330HCID 86736330、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

5-Androstene-3β,17β,19-triol 17,19-diacetate is dissolved in methylenechloride and triethyloxonium fluoroborate added thereto. After stirring for a period of about two hours at room temperature, water is added to the reaction mixture. The methylenechloride layer is dried over magnesium sulfate and concentrated to dryness. The residue is crystallized from an acetone-hexane mixture to yield the desired 3β-ethoxy-5-androstene-17β,19-diol diacetate.

後処理

  1. dry with materialThe methylenechloride layer is dried over magnesium sulfate
  2. concentrationconcentrated to dryness
  3. customThe residue is crystallized from an acetone-hexane mixture

出典と根拠

ORDレコード
ord-65f4e78653ba4f05b345502968f47227
出典データセット
uspto-grants-1979_02
特許番号
US04139617

反応ノート

読み込み中…