Potassium Carbonate → HCID 70605331、化合物

HRID 1390789ノート

反応式

HRID 1390789 の反応式
[C:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:25]([CH2:26][CH2:27][C@:6]12[CH3:7])[C@:19]1([CH2:20][O:21]C(=O)C)[C:14]([CH2:15][C@@H:16]([O:28][CH2:29][CH3:30])[CH2:17][CH2:18]1)=[CH:13][CH2:12]3)(=[O:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:25]([CH2:26][CH2:27][C@:6]12[CH3:7])[C@:19]1([CH2:20][OH:21])[C:14]([CH2:15][C@@H:16]([O:28][CH2:29][CH3:30])[CH2:17][CH2:18]1)=[CH:13][CH2:12]3)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 86736330HCID 86736330、化合物

生成物 1

HCID 70605331HCID 70605331、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3β-Ethoxy-5-androstene-17β,19-diol diacetate is added to an aqueous methanol solution of potassium carbonate and the reaction solution stirred at room temperature for about 2 hours. The reaction mixture is poured onto water, and the oil which results is extracted into ether. The ether extract is washed with water, dried over magnesium sulfate and concentrated to dryness. Crystallization of the residue from an ether-pentane mixture yields 3β-ethoxy-5-androstene-17β,19-diol 17-acetate.

後処理

  1. additionThe reaction mixture is poured onto water
  2. customthe oil which results
  3. extractionis extracted into ether
  4. extractionThe ether extract
  5. washis washed with water
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated to dryness
  8. customCrystallization of the residue from an ether-pentane mixture

出典と根拠

ORDレコード
ord-f74078a0cc58495790ea1fccafc1a9b3
出典データセット
uspto-grants-1979_02
特許番号
US04139617

反応ノート

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