Acetic Acid → 2-[5-(4-Chlorophenyl)-1,2-oxazol-3-yl]benzoic acid
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([C:13]3[CH:22]=[CH:21][CH:20]=[CH:19][C:14]=3[C:15]([O:17]C)=[O:16])[CH:9]=2)=[CH:4][CH:3]=1.Cl.C(O)(=O)C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([C:13]3[CH:22]=[CH:21][CH:20]=[CH:19][C:14]=3[C:15]([OH:17])=[O:16])[CH:9]=2)=[CH:6][CH:7]=1参加物
5
実験手順
A mixture of 2.8 g of methyl 2-[5-(4-chlorophenyl)3-isoxazolyl]benzoate, 12 ml of concentrated HCl, and 14 ml of acetic acid was held at reflux for 4 hours, cooled, diluted with water, and filtered to give 2.55 g (95%) of white solid, mp 174-176° C. Recrystallization of the solid gave 2.18 g of solid, mp 175.5-177.5° C.
後処理
- temperatureat reflux for 4 hours
- temperaturecooled
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-76e74cc7dfa846dba12be70f289f2032
- 出典データセット
- uspto-grants-1979_02
- 特許番号
- US04140515
反応ノート
読み込み中…