3-Fluoro-2-hydroxybenzoic acid → Methyl 3-fluoro-2-hydroxybenzoate

HRID 1390922

反応式

HRID 1390922 の反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=[O:6])[C:3]=1[OH:11].B(F)(F)F.CO.[C:18](=O)(O)[O-].[Na+]>CO>[CH3:18][O:6][C:5](=[O:7])[C:4]1[C:3](=[C:2]([F:1])[CH:10]=[CH:9][CH:8]=1)[OH:11]

参加物

5

反応物 3

HCID 2687243-Fluoro-2-hydroxybenzoic acidHCID 516892Sodium BicarbonateHCID 11062313Boron, trifluoro(methanol)-, (T-4)-

生成物 1

HCID 573875Methyl 3-fluoro-2-hydroxybenzoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A 15.6 g (0.10 mole) portion of 3-fluorosalicylic acid was dissolved in a 100 ml portion of absolute methanol. A 22 ml portion of borontrifluoride-methanol reagent (2 equivalents, 51% BF3) was added and the reaction allowed to reflux for about six hours. The reaction mixture was cooled and added carefully to a saturated solution of sodium bicarbonate. The resulting mixture was then extracted with ether, the ether layer dried over magnesium sulfate and evaporated in vacuo. The oil obtained was crystallized from methanol. The methyl-3-fluorosalicylate obtained had a melting point of 94°-5° C.

後処理

  1. temperatureto reflux for about six hours
  2. temperatureThe reaction mixture was cooled
  3. extractionThe resulting mixture was then extracted with ether
  4. dry with materialthe ether layer dried over magnesium sulfate
  5. customevaporated in vacuo
  6. customThe oil obtained
  7. customwas crystallized from methanol

出典と根拠

ORDレコード
ord-67d48203d25e4475b44bc5781c643097
出典データセット
uspto-grants-1979_02
特許番号
US04140769

関連ノート

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