1-(Difluoromethoxy)-4-isocyanatobenzene → HCID 21332243、化合物

HRID 1390970ノート

反応式

HRID 1390970 の反応式
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]=[C:11]=[O:12])=[CH:6][CH:5]=1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH2:25][CH:24]([C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)[NH:23][N:22]=2)=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[F:1][CH:2]([F:13])[O:3][C:4]1[CH:5]=[CH:6][C:7]([NH:10][C:11]([N:23]2[CH:24]([C:26]3[CH:27]=[CH:28][C:29]([Cl:32])=[CH:30][CH:31]=3)[CH2:25][C:21]([C:18]3[CH:19]=[CH:20][C:15]([Cl:14])=[CH:16][CH:17]=3)=[N:22]2)=[O:12])=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 27333711-(Difluoromethoxy)-4-isocyanatobenzeneHCID 47383511H-Pyrazole, 3,5-bis(4-chlorophenyl)-4,5-dihydro-

生成物 1

HCID 21332243HCID 21332243、化合物収率 35%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

反応条件

温度
80 °C

実験手順

5.55 g (0.03 mol) of 4-difluoromethoxy-phenyl isocyanate in 20 ml of toluene were added, at 50° C., to a solution of 8.74 g (0.03 mol) of 3-(4-chlorophenyl)-5-(4-chlorophenyl)-2-pyrazoline in 100 ml of toluene and the batch was stirred for 2 hours at 80° C. After it had cooled, the product which had precipitated was isolated by filtration. 5 g (35% of theory) of 1-(4-difluoromethoxyphenylcarbamoyl)-3-(4-chlorophenyl)-5-(4-chlorophenyl)-2-pyrazoline of melting point 174° C. were obtained.

後処理

  1. temperatureAfter it had cooled
  2. customthe product which had precipitated
  3. customwas isolated by filtration

出典と根拠

ORDレコード
ord-946fa52f0e644626b95f8d5d0fa3dc16
出典データセット
uspto-grants-1979_02
特許番号
US04140792

反応ノート

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