Acetic Acid → Methyl 4-(4-acetyl-8-hydroxytridecyl)benzoate

HRID 1391175ノート

反応式

HRID 1391175 の反応式
[N+](=C)=[N-].[C:4]([CH:7]([CH2:20][CH2:21][CH2:22][CH:23]([OH:29])[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:8][CH2:9][CH2:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=1)(=[O:6])[CH3:5].[C:30](O)(=O)C>CCOCC>[C:4]([CH:7]([CH2:20][CH2:21][CH2:22][CH:23]([OH:29])[CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([C:15]([O:17][CH3:30])=[O:16])=[CH:18][CH:19]=1)(=[O:6])[CH3:5]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 9550DiazomethaneHCID 203860504-(4-Acetyl-8-hydroxytridecyl)benzoic acid

生成物 1

HCID 20386072Methyl 4-(4-acetyl-8-hydroxytridecyl)benzoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of diazomethane (approximately 2.5 g., 0.06 mole) in ether (100 ml.) is mixed with a solution of 4-(4-acetyl-8-hydroxytridecyl)benzoic acid (10.8 g., 0.03 mole) in ether (50 ml.). The resulting solution is allowed to stand 4 hours at room temperature. Acetic acid is then added to destroy the excess diazomethane and the solution is washed with dilute sodium bicarbonate solution and water and dried over sodium sulfate. Evaporation of volatile materials at reduced pressure yields methyl 4-(4-acetyl-8-hydroxytridecyl)benzoate, a colorless viscous oil.

後処理

  1. customto destroy the excess diazomethane
  2. washthe solution is washed with dilute sodium bicarbonate solution and water
  3. dry with materialdried over sodium sulfate
  4. customEvaporation of volatile materials at reduced pressure

出典と根拠

ORDレコード
ord-83197c821b1343e3961f39fa08eca0e6
出典データセット
uspto-grants-1979_02
特許番号
US04140861

反応ノート

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