Bromine → HCID 20386067、化合物

HRID 1391182ノート

反応式

HRID 1391182 の反応式
[C:1]([CH2:3][C:4]1[CH:14]=[CH:13][C:7]([CH2:8][CH2:9]C(O)=O)=[CH:6][CH:5]=1)#[N:2].[Br:15]Br>C(Cl)(Cl)(Cl)Cl>[Br:15][CH2:9][CH2:8][C:7]1[CH:13]=[CH:14][C:4]([CH2:3][C:1]#[N:2])=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 24408BromineHCID 20386113p-Cyanomethylhydrocinnamic acid

生成物 1

HCID 20386067HCID 20386067、化合物

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of p-cyanomethylhydrocinnamic acid (18.9 g., 0.1 mole), red mercuric oxide (17.2 g., 0.08 mole), and carbon tetrachloride (180 ml.) is stirred at room temperature while bromine (16.0 g., 0.1 mole) is added dropwise during 40 minutes. The resulting mixture is heated at reflux for 1 hour. The mixture is then cooled, filtered, washed with dilute hydrochloric acid and water, and dried over magnesium sulfate. The solution is evaporated to leave the product as a yellow residual oil. It is purified by column chromatography on silica gel with benzene elution.

後処理

  1. additionis added dropwise during 40 minutes
  2. temperatureThe resulting mixture is heated
  3. temperatureat reflux for 1 hour
  4. temperatureThe mixture is then cooled
  5. filtrationfiltered
  6. washwashed with dilute hydrochloric acid and water
  7. dry with materialdried over magnesium sulfate
  8. customThe solution is evaporated

出典と根拠

ORDレコード
ord-6e5555c151b8455999b2be8f4d480166
出典データセット
uspto-grants-1979_02
特許番号
US04140861

反応ノート

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