Ethanol → Ethyl [4-(2-Bromoethyl)phenyl]acetate

HRID 1391184ノート

反応式

HRID 1391184 の反応式
[Br:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1.S(=O)(=O)(O)O.[CH2:19](O)[CH3:20]>>[Br:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([O:13][CH2:19][CH3:20])=[O:12])=[CH:6][CH:5]=1

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 20386065[4-(2-Bromoethyl)phenyl]acetic acid

生成物 1

HCID 54408832Ethyl [4-(2-Bromoethyl)phenyl]acetate

実験手順

A solution of [4-(2-bromoethyl)phenyl]acetic acid (48.6 g., 0.2 mole) and sulfuric acid (1.5 ml.) in ethanol (400 ml.) is boiled under reflux for 6 hours. About 300 ml. of the ethanol is removed by distillation at reduced pressure. The residue is diluted with 400 ml. of water. The oily ester is taken up in ether, washed with water and brine, and dried over magnesium sulfate. Evaporation of the ether leaves the title compound as an oil which can be purified by distillation in vacuo.

後処理

  1. temperatureunder reflux for 6 hours
  2. customof the ethanol is removed by distillation at reduced pressure
  3. additionThe residue is diluted with 400 ml
  4. washwashed with water and brine
  5. dry with materialdried over magnesium sulfate
  6. customEvaporation of the ether

出典と根拠

ORDレコード
ord-cf55b2ce491647c0a5b0b8667929280f
出典データセット
uspto-grants-1979_02
特許番号
US04140861

反応ノート

読み込み中…