Cyanogen Bromide → 1-methyl-5-nitro-1H-benzimidazol-2-amine

HRID 1391546ノート

反応式

HRID 1391546 の反応式
[CH3:1][NH:2][C:3]1[C:4]([NH2:12])=[CH:5][C:6]([N+:9]([O-:11])=[O:10])=[CH:7][CH:8]=1.[N:13]#[C:14]Br>CO>[CH3:1][N:2]1[C:3]2[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=2[N:12]=[C:14]1[NH2:13]

参加物

4

反応物 2

HCID 10476Cyanogen BromideHCID 34200251-N-methyl-4-nitrobenzene-1,2-diamine

生成物 1

HCID 450786361-methyl-5-nitro-1H-benzimidazol-2-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of N1-methyl-4-nitro-benzene-1,2-diamine (200 mg, 1.20 mmol) in methanol (12 ml) was added cyanogen bromide (190.1 mg, 1.79 mmol). After stirring at room temperature for 16 h, the methanol was removed in vacuo and the resulting solid was stirred with diethyl ether (40 ml) for 5 minutes. The resulting hydrobromide salt of the title compound was filtered and air-dried.

後処理

  1. customthe methanol was removed in vacuo
  2. stirringthe resulting solid was stirred with diethyl ether (40 ml) for 5 minutes
  3. filtrationThe resulting hydrobromide salt of the title compound was filtered
  4. customair-dried

出典と根拠

ORDレコード
ord-a44532fd00534422a86455a70c8c0659
出典データセット
uspto-grants-2008_03
特許番号
US07338959B2

反応ノート

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