Hydrazine → HCID 45078395、化合物

HRID 1391548ノート

反応式

HRID 1391548 の反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([N+:11]([O-])=O)=[CH:10][C:5]=2[N:4]=[C:3]1[NH2:14].NN>C(O)C>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([NH2:11])=[CH:10][C:5]=2[N:4]=[C:3]1[NH2:14]

参加物

4

反応物 2

HCID 9321HydrazineHCID 450786361-methyl-5-nitro-1H-benzimidazol-2-amine

生成物 1

HCID 45078395HCID 45078395、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of 1-Methyl-5-nitro-1H-benzoimidazol-2-ylamine (0.19 g, 1 mmol) 10% Pd/C (50 mg) in ethanol (10 ml) was added hydrazine (0.5 ml) and the reaction was heated to 80° C. After TLC showed the starting material to be consumed, the reaction was cooled to rt and passed through a plug of celite. The filtrate was concentrated to give the title compound as an off-white solid. MS (ESI) m/z=163 [M+H]+.

後処理

  1. customto be consumed
  2. temperaturethe reaction was cooled to rt
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-32cab314128b474a870fd013758380bd
出典データセット
uspto-grants-2008_03
特許番号
US07338959B2

反応ノート

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