(Oxan-4-yl)methanesulfonyl chloride → 4-(Acetylthiomethyl)tetrahydropyran

HRID 1392143ノート

反応式

HRID 1392143 の反応式
Cl[S:2]([CH2:5][CH:6]1[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1)(=O)=O.[CH2:12]([O:19]C(C1(CS(N2CCN(C3C=CC(F)=CC=3)CC2)(=O)=O)CCOCC1)=O)[C:13]1C=CC=CC=1.FC1C=CC(N2CCN(S(CC3(C(O)=O)CCOCC3)(=O)=O)CC2)=CC=1>>[C:12]([S:2][CH2:5][CH:6]1[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1)(=[O:19])[CH3:13]

参加物

4

反応物 3

HCID 18348392(Oxan-4-yl)methanesulfonyl chlorideHCID 227197264-[4-(4-Fluorophenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acidHCID 691988074-[4-(4-Fluorophenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid benzyl ester

生成物 1

HCID 597040184-(Acetylthiomethyl)tetrahydropyran

実験手順

MS (ESI): 331 (MNa+); 4-(chlorosulfonylmethyl)tetrahydropyran-4-(carboxylic acid benzyl ester): MS (ESI): 354 (MNa+); 4-[4-(4-fluorophenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid benzyl ester: MS (ESI): 477 (MH+), 499 (MNa+); 4-[4-(4-fluorophenyl)piperazine-1-sulfonylmethyl]tetrahydropyran-4-carboxylic acid: MS (ESI): 387 (MH+), 409 (MNa+).

出典と根拠

ORDレコード
ord-4455bc473f8b403f89529abfba0176da
出典データセット
uspto-grants-2008_03
特許番号
US07342020B2

反応ノート

読み込み中…