関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | 3-Furanmethanol | HCID 20449 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-(Benzylsulfanyl)-5-chloro-1,2,4-thiadiazole | HCID 12151383 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-(3-Furyl)methoxy-3-benzylthio-1,2,4-thiadiazole | HCID 23079397 | 55.9% |
反応手順
To 2 g of N,N-dimethylformamide, 0.243 g of 5-chloro-3-benzylthio-1,2,4-thiadiazole and 0.098 g of 3-furanmethanol were dissolved, and added 0.045 g of sodium hydride (60% in oil) at about 0° C., followed by stirring at about 0° C. for 1 hour and at room temperature for 2 hours. Then, the reaction mixture was added to saturated sodium chloride aqueous solution, and extracted with tert-butylmethylether. The organic layer was concentrated, and the residue obtaind was subjected to silica gel column chromatography to obtain 0.17 g of 5-(3-furyl)methoxy-3-benzylthio-1,2,4-thiadiazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07342031B2 |
|---|
| 出典データセット | uspto-grants-2008_03 |
|---|
| ORD ID | ord-cc76016f38a04ab4a6dbbf57817c0e50 |
|---|
| 出典メモ | uspto-grants-2008_03 |
|---|
