Triethylamine → 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-[2-[N-(2,5-dihydropyrrol-1-yl)amino]phenyl]piperidin-3-ol

HRID 1392394

反応式

C(OC/C=C\COC(=O)C)(=O)C.[O:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[CH:15]=[C:14]1[C:22]([NH:24][C:25]1([C:31]([NH:33][CH:34]2[CH2:39][CH2:38][N:37]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=3[NH2:46])[CH2:36][CH:35]2[OH:47])=[O:32])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:23].[CH2:48]([N:50](CC)[CH2:51][CH3:52])[CH3:49]>ClCCl.CN(C)C=O>[O:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[CH:15]=[C:14]1[C:22]([NH:24][C:25]1([C:31]([NH:33][CH:34]2[CH2:39][CH2:38][N:37]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=3[NH:46][N:50]3[CH2:51][CH:52]=[CH:49][CH2:48]3)[CH2:36][CH:35]2[OH:47])=[O:32])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1)=[O:23]

参加物

実験手順

To the solution of cis-2-buten-1,4-diol diacetate (1.15 g) in 30 ml of dichloromethane, was added the solution of 4-[N-[1-[N-(benzofuran-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-(2-aminophenyl)piperidin-3-ol (1.5 g) obtained in Step 2 of Example 43 in 20 ml of dimethylformamide. 0.44 ml of triethylamine was added to the reaction mixture, which was then stirred overnight at room temperature. 20 ml of ice water was added to the reaction mixture. The resulting organic layer was dried and concentrated on sodium sulfate. The resulting residue was purified with column chromatography to give 0.7 g of the titled compound.

後処理

customThe resulting organic layer was dried
concentrationconcentrated on sodium sulfate
customThe resulting residue was purified with column chromatography

出典と根拠

ORDレコード: ord-47f93341a4844ddd87136e847c149cf4
出典データセット: uspto-grants-2008_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07342027B2

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

関連ノート