Hydrogen chloride-ethyl acetate → HCID 69312995、化合物

HRID 1392411ノート

反応式

HRID 1392411 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][C:9]1([C:15]([NH:17][CH:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH:19]2[OH:31])=[O:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7].[ClH:32].C(OCC)(=O)C>C(OCC)C>[ClH:32].[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][C:9]1([C:15]([NH:17][CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH:19]2[OH:31])=[O:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7]

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 693103074-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-1-tert-butoxycarbonyl-3-piperidinol

生成物 1

HCID 69312995HCID 69312995、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

The solution of 4-{1-[N-(furan-2-ylcarbonyl)amino]cyclohexane carbonyl}amino-1-tert-butoxycarbonyl-3-piperidinol (30 g) obtained in Step 3 in 100 ml of 3N-hydrochloride/ethyl acetate was stirred for about 2 hours at room temperature. 100 ml of diethyl ether was added to the reaction mixture, and then the resulting white solid was filtered and dried to give 3.6 g of the titled compound.

後処理

  1. filtrationthe resulting white solid was filtered
  2. customdried

出典と根拠

ORDレコード
ord-e7dc10ff0d1949d3b6719441892f4b7a
出典データセット
uspto-grants-2008_03
特許番号
US07342027B2

反応ノート

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