Methyl 3-chloro-4-fluoro-alpha-azidocinnamate → Methyl 5-chloro-6-fluoro-1H-indole-2-carboxylate

HRID 1392724ノート

反応式

HRID 1392724 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[F:17])[CH:5]=[C:6]([N:11]=[N+]=[N-])[C:7]([O:9][CH3:10])=[O:8]>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:14](=[CH:15][C:16]=1[F:17])[NH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5]2

参加物

3

反応物 1

HCID 54554773Methyl 3-chloro-4-fluoro-alpha-azidocinnamate

生成物 1

HCID 18986230Methyl 5-chloro-6-fluoro-1H-indole-2-carboxylate

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A mixture of methyl 3-chloro-4-fluoro-α-azidocinnamate (Japanese Patent Application Laid-Open No. 149723/1995) (1.85 g) and xylene (140 ml) was heated under reflux for 1 hour, and the solvent was then distilled off. The residue was purified by column chromatography on silica gel (methylene chloride) to obtain the title compound (491 mg).

後処理

  1. temperatureunder reflux for 1 hour
  2. distillationthe solvent was then distilled off
  3. customThe residue was purified by column chromatography on silica gel (methylene chloride)

出典と根拠

ORDレコード
ord-236c3c0a2fbd432f872306dece760f78
出典データセット
uspto-grants-2008_03
特許番号
US07342014B2

反応ノート

読み込み中…