Hydrochloric Acid → HCID 23133306、化合物

反応式

Cl.C(OC([N:9]1[CH2:14][CH2:13][CH:12]([C:15]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][C:21]([O:29][CH3:30])=[C:22]([O:27][CH3:28])[CH:23]=3)[CH2:18]2)=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C>CCOCC.C(OCC)(=O)C>[CH3:28][O:27][C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][C:21]=1[O:29][CH3:30])[CH2:18][N:17]([C:15]([CH:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1)=[O:16])[CH2:26][CH2:25]2

参加物

実験手順

A solution of 5 N hydrochloric acid in ether (5 ml) was added to a solution of 4-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester (3 g, 7.43 mmol) in ethyl acetate and the mixture was stirred for 2 hours at room temperature. The precipitate formed was collected by filtration and the white solid obtained was indetified as (6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(piperidin-4-yl)-methanone (2.1 g, 95% yield).