Dimethylamine → HCID 23144875、化合物

HRID 1393056ノート

反応式

HRID 1393056 の反応式
Br[CH2:2][C:3]1[C:4]([N+:13]([O-:15])=[O:14])=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7].[CH3:16][NH:17][CH3:18]>CO>[CH3:16][N:17]([CH2:2][C:3]1[C:4]([N+:13]([O-:15])=[O:14])=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7])[CH3:18]

参加物

4

反応物 2

HCID 674DimethylamineHCID 22509333Methyl 3-(bromomethyl)-2-nitrobenzoate

生成物 1

HCID 23144875HCID 23144875、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

Methyl 3-bromomethyl-2-nitrobenzoate (1.6 g) was dissolved in methanol (5 mL). Methanol solution (6 mL) of 2M dimethylamine was added thereto and stirred overnight. After removing the solvent, the residue was diluted with 1M hydrochloric acid and washed with ethyl acetate. The water layer was alkalized with sodium hydrate aqueous solution and extracted with ethyl acetate. The usual workup procedure was conducted to obtain methyl 3-dimethylaminomethyl-2-nitrobenzoate.

後処理

  1. customAfter removing the solvent
  2. additionthe residue was diluted with 1M hydrochloric acid
  3. washwashed with ethyl acetate
  4. extractionextracted with ethyl acetate

出典と根拠

ORDレコード
ord-262f6b9ddb8a4538a5013e4c716fa0b8
出典データセット
uspto-grants-2008_03
特許番号
US07345049B2

反応ノート

読み込み中…