1,4-Dioxane hydrochloride → HCID 67118563、化合物
反応式
[ClH:1].O1CCOCC1.[C:8]12([CH2:18][CH2:19][N:20]([CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[C:21]([C@H:23]3[CH2:27][CH2:26][CH2:25][N:24]3C(OC(C)(C)C)=O)=[O:22])[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2>>[ClH:1].[C:8]12([CH2:18][CH2:19][N:20]([CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[C:21]([C@H:23]3[CH2:27][CH2:26][CH2:25][NH:24]3)=[O:22])[CH2:9][CH:10]3[CH2:11][CH:12]([CH2:13][CH:14]([CH2:16]3)[CH2:15]1)[CH2:17]2参加物
3
実験手順
Next, 4 N hydrogen chloride/dioxane (20 ml, 81 mmol) was added to (R)-1-(t-butoxycarbonyl)-2-pyrrolidinecarboxylic acid N-[2-(1-adamantyl)ethyl]-N-pentylamide (1.8 g, 4.0 mmol) under ice-cooling, then the temperature was raised to room temperature, and the mixture was stirred for 1.5 hours. The reaction mixture was concentrated under reduced pressure to give 1.5 g (quantitatively) of (R)-2-pyrrolidinecarboxylic acid N-[2-(1-adamantyl)ethyl]-N-pentylamide hydrochloride as a noncrystalline solid.
後処理
- temperaturecooling
- concentrationThe reaction mixture was concentrated under reduced pressure