Hydrochloric Acid → 2-{4-[(3,7-Dimethyl-2,6-octadienyl)oxy]phenyl}acetic acid

HRID 1393849ノート

反応式

HRID 1393849 の反応式
[OH-].[K+].[CH3:3][C:4]([CH2:19][CH2:20][CH:21]=[C:22]([CH3:24])[CH3:23])=[CH:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17]C)=[O:16])=[CH:10][CH:9]=1.Cl>CO>[CH3:3][C:4]([CH2:19][CH2:20][CH:21]=[C:22]([CH3:24])[CH3:23])=[CH:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([OH:17])=[O:16])=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 69306599Methyl 2-{4-[(3,7-dimethyl-2,6-octadienyl)oxy]phenyl}acetate

生成物 1

HCID 545318442-{4-[(3,7-Dimethyl-2,6-octadienyl)oxy]phenyl}acetic acid収率 61%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1N potassium hydroxide (46 ml) was added to a solution of methyl 2-{4-[(3,7-dimethy-2,6-octadienyl)oxy]phenyl}acetate (9.46 g, 31.28 mmol) in methanol (70 ml) and refluxed for 1 hour. The mixture, with 3N hydrochloric acid (50 ml) added thereto, was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over MgSO4, and then concentrated. The residue was purified by recrystallization (ethyl acetate/hexane), to give 2-{4-[(3,7-dimethyl-2,6-octadienyl)oxy]phenyl}acetic acid (5.50 g, 61%).

後処理

  1. temperaturerefluxed for 1 hour
  2. extractionwas extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. customThe residue was purified by recrystallization (ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-12646011c54340569cd697ee92dfad55
出典データセット
uspto-grants-2008_03
特許番号
US07348017B2

反応ノート

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