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Methyl p-toluenesulfonate → (+/-)-Benzyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl p-toluenesulfonate | HCID 6645 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | (+/-)-(5-Chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylamine | HCID 11436234 | — |
| 生成物 | (+/-)-Benzyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate | HCID 86598555 | 89% |
反応手順
Treatment of (±)-1-(5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methanamine (0.83 g, 3.07 mmol) with diisopropylethylamine (1.20 g, 9.28 mmol) followed by benzyl chloroformate (0.79 g, 4.60 mmol) generally according to the procedure described for Intermediate 7 provided 1.00 g (89%) of (±)-benzyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate as a white solid. mp 117-119° C.; Anal. calcd. for C21H18ClNO3.0.5H2O: C, 66.93; H, 5.08; N, 3.72. Found: C, 66.81; H, 4.96; N, 3.67.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728155B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-92529086747c42debf7858c6e4eac049 |
| 出典メモ | uspto-grants-2010_06 |