Ethyl 3-bromo-2-oxocyclohexanecarboxylate → Ethyl 2-amino-4,5,6,7-tetrahydrobenzthiazole-4-carboxyate hydrobromide

HRID 1394103

反応式

HRID 1394103 の反応式
[Br:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]1=O.[NH2:14][C:15]([NH2:17])=[S:16]>C(O)C>[BrH:1].[NH2:17][C:15]1[S:16][C:2]2[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]=2[N:14]=1

参加物

4

反応物 2

HCID 121765Ethyl 3-bromo-2-oxocyclohexanecarboxylateHCID 2723790Thiourea

生成物 1

HCID 87730500Ethyl 2-amino-4,5,6,7-tetrahydrobenzthiazole-4-carboxyate hydrobromide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethanol (50 mL) was added to ethyl 3-bromo-2-oxocyclohexane-carboxylate (50 g, 0.20 mol) and thiourea (15.3 g, 0.20 mol) and the reaction mixture was stirred for a period of 24 hours at room temperature under a blanket of nitrogen as inert gas. Following the removal of the solvent, ether (100 mL) was added to the residue. Following stirring for a period of 2 hours at room temperature, the suspension was filtered off and the solid matter was dried in vacuo. The product ethyl 2-amino-4,5,6,7-tetrahydrobenzthiazole-4-carboxyate hydrobromide was obtained in a yield of 58.6 g (corresponding to 95% of theory).

後処理

  1. customthe removal of the solvent, ether (100 mL)
  2. additionwas added to the residue
  3. stirringFollowing stirring for a period of 2 hours at room temperature
  4. filtrationthe suspension was filtered off
  5. customthe solid matter was dried in vacuo

出典と根拠

ORDレコード
ord-9de07cbf27934ee28b6af45750699deb
出典データセット
uspto-grants-2008_03
特許番号
US07348347B2

関連ノート

読み込み中…