化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl Acetate → 2'-Chloro[1,1'-biphenyl]-4-carbaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 1-Bromo-2-chlorobenzene | HCID 12754 | — |
| 反応物 | 4-Formylphenylboronic Acid | HCID 591073 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2'-Chloro[1,1'-biphenyl]-4-carbaldehyde | HCID 1394400 | — |
反応手順
To a solution of 2-bromochlorobenzene (0.24 mL, 2 mmol) and 4-formylbenzeneboronic acid (0.35 g, 2.2 mmol) in toluene (20 mL) were added 2M aq. sodium carbonate (2.6 mL) followed by (Ph3P)4Pd (0.34 g, 0.3 mmol). The resulting reaction mixture was refluxed for 3 h, cooled and diluted ethyl acetate. The organic phase was washed with water, saturated aq. sodium bicarbonate, brine and dried over sodium sulfate. The filtrate was concentrated in vacuo and the residue obtained was purified by chromatography (hexane:ethyl acetate; 4:1) to yield the title product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07348348B2 |
| 出典データセット | uspto-grants-2008_03 |
| ORD ID | ord-c73cff83589e435d93d15875f07dee8c |
| 出典メモ | uspto-grants-2008_03 |